Keywords

• Cyclopenta[c]pyrrole-1-carboxamide,(2S)-2-cyclohexyl-N-(pyrazinylcarbonyl)glycyl-3-methyl-L-valyl-N-[(1S)-1-[(cyclopropylamino)oxoacetyl]butyl]octahydro-,(1S,3aR,6aS)- (9CI)
• LY 570310
• MP 424

Quick Details

• ProName: Cyclopenta(c)pyrrole-1-carboxamide, (2...
• CasNo: 402957-28-2
• Molecular Formula: C36H53N7O6
• Appearance: Pale Yellow to Light Yellow
• ProductionCapacity: /
• Purity: 98
• Storage: Sealed in dry,Store in freezer, under ...
• LimitNum: 0
• density: 1.3±0.1 g/cm3
• molecular weight: 679.849
• Precise mass: 679.405762
• PSA: 179.56000
• LogP: 3.93
• refractive index : 1.584

Superiority

Jilin Tianyun New Materials Co., Ltd. is a professional production enterprise that production, processing, and export, mainly engaged in various organic chemicals. The company has a wealth of professional experience, reliable product quality, reasonable prices, and products are exported to countries around the world, which can meet your diverse needs. In our business cooperation with clients, we always adhere to the principle of equality and mutual benefit, and are deeply trusted and recognized by our clients. If you are interested in our company and our products, please feel free to visit our website or contact us directly for more information.We look forward to establishing a long-term stable and win-win business relationship with you.

Details

Telaprevir is a potent and selective reversible HCV NS3-4A protease inhibitor with a Ki of 7 nM for genotype 1 (H strain) NS3 protease domain and NS4A cofactor peptide.

Telaprevir (VX-950) is a covalent, reversible NS3-4A protease inhibitor with a slow binding and slow dissociation mechanism. Telaprevir exhibits significantly different kinetics in enzyme inhibition, the most obvious example of which is the very long half-life (58 min) of bound enzyme-inhibitor complexes. Telaprevir has a moderate synergistic effect with IFN-α in inhibiting HCV replication and inhibiting the emergence of resistance in replicon cells. Telaprevir decreases HCV RNA levels in a time- and dose-dependent manner. IC50s after 24, 48, 72, and 120 h incubation with Telaprevir are determined to be 0.574, 0.488, 0.21, and 0.139 μM, respectively, indicating that the inhibition effect increases with time. After three independent experiments using a 48-hour incubation in the presence of 2% FBS, the mean IC50 of Telaprevir is determined to be 0.354±0.035 μM, and the mean IC90 is 0.830±0.190 μM[1]. Telaprevir (VX-950) is a potent and selective peptide mimetic inhibitor of hepatitis C virus (HCV) NS3-4A serine protease, and Telaprevir exhibits excellent antiviral activity in genotype 1b HCV replicon cells (IC50=354 nM) and in humans. Fetal hepatocellular infection genotype 1a HCV-positive patients with serum (IC50=280 nM)