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Jilin Tianyun New Materials Co., Ltd

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Jilin Tianyun New Materials Co., Ltd

Country: China (Mainland)

Business Type:Trading Company

Mr.wang

Tel: 86-1863412-4001

Ms.Rabbi

Tel: 18744151320

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Ms.Vita

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City: Changchun

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trimetazidine dihydrochloride

CAS NO.13171-25-0

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Product Details

Keywords

  • Piperazine, 1-(2,3,4-trimethoxybenzyl)-, dihydrochloride
  • Kyurinett
  • Piperazine, 1-((2,3,4-trimethoxyphenyl)methyl)-, dihydrochloride (9CI)

Quick Details

  • ProName: Trimetazidine dihydrochloride
  • CasNo: 13171-25-0
  • Molecular Formula: C14H24Cl2N2O3
  • Appearance: Crystalline solids
  • ProductionCapacity: /
  • Purity: 99
  • Storage: Room temperature is sealed, cool, vent...
  • LimitNum: 0
  • boiling point : 364oC at 760 mmHg
  • melting point : 231-235 °C(lit.)
  • molecular weight: 339.258
  • flash point: 174oC
  • Precise mass : 338.116394
  • PSA: 42.96000
  • LogP: 2.98830

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Jilin Tianyun New Materials Co., Ltd. is a professional production enterprise that production, processing, and export, mainly engaged in various organic chemicals. The company has a wealth of professional experience, reliable product quality, reasonable prices, and products are exported to countries around the world, which can meet your diverse needs. In our business cooperation with clients, we always adhere to the principle of equality and mutual benefit, and are deeply trusted and recognized by our clients. If you are interested in our company and our products, please feel free to visit our website or contact us directly for more information.We look forward to establishing a long-term stable and win-win business relationship with you.

Details

Use of 1-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride

 

tip


Trimetazidine dihydrochloride is an angina pectoris that acts as the first cell-protective anti-ischemic agent to improve myocardial glucose utilization by inhibiting fatty acid metabolism.

 1-(2,3,4-trimethoxybenzyl)piperazine dihydrochloride effect

 

tip


Trimetazidine hydrochloride belongs to other classes of anti-angina drugs, suitable for the preventive treatment of angina attacks, auxiliary symptomatic treatment of vertigo and tinnitus, with the effect of anti-adrenaline, norepinephrine and vasopressin, can reduce vascular resistance, increase coronary and circulatory blood flow, promote myocardial metabolism and myocardial energy production. At the same time, it can reduce myocardial oxygen consumption, thereby improving the balance of myocardial oxygen supply and demand. It can also increase the tolerance of cardiac glycosides.
Controlled trials in patients with angina have shown that:


1. Trimetazidine hydrochloride can increase the exercise test tolerance of patients with angina, delay exercise-induced myocardial ischemia from the treatment of DL5, reduce ischemia, but do not cause hemodynamic changes.
2. Limiting rapid blood pressure fluctuations does not cause significant changes in heart rate and significantly reduces the frequency of angina attacks.
3. The dosage of nitroglycerin is significantly reduced.
Trimetazidine prevents the decline of intracellular ATP levels by protecting the energy metabolism of cells in the case of hypoxia or ischemia, thereby ensuring the normal function of the ion pump and the normal operation of permeable sodium-potassium flow, reducing intracellular acidosis and preventing the accumulation of sodium and calcium in cardiomyocytes, protecting cell contractile function and limiting cytolysis and intimal damage caused by oxygen free radicals, and maintaining the stability of the intracellular environment.

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